Protein Sciences Corporation;David Rhodes;Kathleen Holtz
发明人:
Rhodes, David,Holtz, Kathleen
申请号：
AU2014234034
公开号：
AU2014234034A1
申请日:
2014.03.13
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention relates to methods of improving the stability and maintaining the potency of recombinant hemagglutinin formulations, in particular, recombinant influenza hemagglutinin (rHA). In particular, applicants have shown that the stability of rHA formulations may be significantly improved by mutating cysteine residues or by formulating with a reducing agent and sodium citrate.
