INHIBITEURS DE HDAC

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专利权人:

LIXTE BIOTECHNOLOGY; INC.

发明人:

KOVACH, JOHN S.,JOHNSON, FRANCIS

申请号：

CA2700857

公开号：

CA2700857C

申请日:

2008.10.01

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

This invention providesthe compound having the structurewherein n is 1- 10； X is C-R11 or N,wherein R11 is H, OH, SH, F, Cl, SO2R7,NO2, trifluoromethyl, methoxy, orCO-R7, wherein R7 is alkyl, alkenyl,alkynyl, C3-C8 cycloalkyl, or aryl； R2 isH or NR3R4, wherein R3 and R4 are eachindependently H, C1-C6 alkyl, or C3-C8cycloalkyl； R5 is OH or SH； and R6,R12A R13, and R14are each independentlyH, OH, SH, F, Cl, SO2R15, NO2,trifluoromethyl, methoxy, or CO-R15,wherein R15 is alkyl, alkenyl, alkynyl,C3-C8 cycloalkyl, or aryl, or a salt ofthe compound, which is useful in thetreatment of tumors.

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