The present invention relates to a chewing gum for mucosal delivery ofcannabinoids, the chewing gum being formulated as an extruded chewing gumcomprising water-soluble chewing gum ingredients mixed into water-insolublegumbase, wherein the chewing gum comprises one or more cannabinoids, and whereinthe chewing gum generates saliva and delivers at least 10% by weight of theone ormore cannabinoids to the oral mucosa during the first 5 minutes of chewing.