BRITTON KENNETH CORKEY,CHANDRASEKAR VENKATARAMANI,DMITRY KOLTUN,ELFATIH ELZEIN,ERIC Q. PARKHILL,JEFF ZABLOCKI,JUAN GUERRERO,MICHAEL GRAUPE,RAO V. KALLA,ROBERT H. JIANG,RUBEN MARTINEZ,THAO PERRY,XIAOFE
申请号:
BR112013032027
公开号:
BR112013032027A2
申请日:
2012.06.29
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.