Tri-specific binding molecules are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. A novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions are provided.一種三特異性結合分子，其是具備三個結合結構域的多鏈多肽分子，因此能夠介導與三個表位的配位結合。此些結合結構域受選，以使得三特異性結合分子能夠結合任何三個不同表位。此些表位可以是相同抗原的表位或兩個或三個不同抗原的表位。在一些實施方式中，第一個表位能夠結合CD3，第二個表位能夠結合CD8，和第三個表位能夠結合疾病相關的抗原的表位。此外，更提供一種新的ROR1結合抗體、其衍生物以及此些組合物的用途。
