The current disclosure provides binding polypeptides (e.g. antibodies) and targeting moiety conjugates thereof comprising a site specifically engineered glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen binding polypeptides recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using the antigen binding polypeptides disclosed herein to treat disease are also provided.
