Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes

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专利权人:

Macau University of Science and Technology

发明人:

BAI, Li-Ping,JIANG, Zhi-Hong

申请号：

AU2014100708

公开号：

AU2014100708A4

申请日:

2014.06.24

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2014100708A420140724.pdf#####Recognition of Chelerythrine to Human Telomeric DNA and RNA G-quadruplexes ABSTRACT A comprehensive study on binding of chelerythrine, a natural antitumor benzophenanthridine alkaloid, to human telomeric DNA/RNA G-quadruplexes was performed by using DNA polymerase stop assay, UV-melting, ESI-TOF-MS and UV-Vis absorption spectrophotometry in this application. The study shows that chelerythrine be a promising candidate for shortening telomeres of cancer cells with the potential application in cancer treatment 24 M006.033.DRF Spec v.1

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