1. This method provides a method for the treatment or prevention of various forms of glycerin (GBM), which is characterized by the expression and / or methyl state of promoter 06 methylguanine DNA methyltransferase (Mgmt)； This includes the effective management of dihydropyridine pyridine compounds to a polymorphic glycerine patient, characterized by the promoter's expression of 06 methylguanina DNA methyltransferase (Mgmt) and / or methyl status.Se proporcionan en la presente métodos para tratar o prevenir glioblastoma multiforme (GBM) caracterizado por la expresión y/o estado de metilación del promotor de 06-metilguanina-ADN metiltransferasa (MGMT), que comprende administrar una cantidad efectiva de un compuesto de Dihidropirazino-Pirazina a un paciente que tiene glioblastoma multiforma (GBM) caracterizado por la expresión y/o estado de metilación del promotor de 06-metilguanina-ADN metiltransferasa (MGMT).
