The present invention provides the new compositions and method for preventing and treating pathogen infection. Specifically, compound provided by the invention have by this compound be anchored to target cell surface anchoring domain and can be in extracellular effect to prevent pathogen (such as viral) to the treatment domain of the infection of target cell. The present invention also includes the therapeutic combination with sialidase activity, this composition contains the compound of the base what albumen with sialidase catalytic domain. Pathogenic infection can be treated with what or be prevented to the compounds of this invention, and can treat and reduce allergy and inflammatory response with what. Present invention provides improve composition and method of the recombinant virus to target cell transduction with what. These compositions and method can be used in gene therapy.本發明提供了預防和治療病原感染的新的組合物和方法。具體而言，本發明提供的化合物具有將此化合物錨定到靶細胞表面的錨定域和能在細胞外作用以防止病原體（例如病毒）對靶細胞的感染的治療域。本發明也包括具有唾液酸酶活性的治療組合物，此組合物含具有唾液酸酶催化域的基於蛋白的化合物。本發明化合物可用於治療或者預防病原體感染，並且可用於治療和減少過敏及發炎反應。本發明也提供了用於提高重組病毒向靶細胞轉導的組合物和方法。這些組合物和方法可在基因治療中得以運用。
