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MICROPARTICLE OF HARDLY-SOLUBLE SUBSTANCE HAVING ENTERIC BASE MATERIAL ADSORBED ON THE SURFACE OF THE SUBSTANCE
专利权人:
ASTELLAS PHARMA INC.
发明人:
YAMAGUCHI, HISAMI,TOMINAGA, TETSUO
申请号:
EP06783174
公开号:
EP1923051A4
申请日:
2006.09.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to fine particles of a poorly soluble drug to provide pharmaceutical preparation having an improved absorption by improving dissolution profile of a poorly soluble drug having a poor absorbability, as well as a method for producing the same. In particular, the present invention relates to fine particles of a poorly soluble drug, having an average particle diameter of 1 nm to 1,000 nm, wherein a particular type of an enteric base material is adsorbed on the surface of the poorly soluble drug, fine particles which further comprises a saccharide, as well as a method for producing the same. It is possible to efficiently and safely produce in a short amount of time fine particles with which absorption of a poorly soluble drug that is poorly absorbed in humans, and the like can be improved, and a pharmaceutical preparation with excellent dispersion stability can be provided, by using the fine particles of the present invention having an improved dissolution profile.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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