The present invention provides the new pyridine base amion acetic acid compound that a kind of the following general formula (1) indicates or its pharmacologically permissible salt, and in following formula, R1, R2, R3, Y and Z are as defined in specification and claims. The Pyridylaminoacetic acid compound has EP2 agonism by what, therefore can be used as the medicine and/or preventive medicine of the respiratory disease such as asthma or Chronic Obstructive Pulmonary Disease.本發明提供一種下述通式(1)表示的新型吡啶基氨基乙酸化合物或其藥理學上可容許的鹽，下式中，R1、R2、R3、Y和Z如說明書和權利要求書中所定義。該吡啶基氨基乙酸化合物由於具有EP2激動作用，因此能夠用作例如哮喘或慢性阻塞性肺疾病等呼吸系統疾病的治療藥和／或預防藥。
