NAGANAWA, ATSUSHI,长绳厚志,長繩厚志,KUSUMI, KENSUKE,久须美健介,久須美健介,OTSUKI, KAZUHIRO,大槻和裕,SEKIGUCHI, TETSUYA,关口哲也,關口哲也,KAKUUCHI, AKITO,角内章人,角內章人,SHINOZAKI, KOJI,筱崎恒二,篠崎恒二,YAMAMOTO, HIROSHI,山本宽,山本寬,NONAKA, SH
申请号：
TW101135621
公开号：
TW201319036A
申请日:
2012.09.27
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A compound represented by general formula (I-1) (where all of the symbols are as defined in the specification) has a powerful human S1P2 antagonist action as a result of the introduction of two cyclic groups, particularly phenoxy groups, at predetermined substitution positions of said compound. It is therefore possible to obtain a therapeutic agent for S1P2-mediated disease, such as vasoconstriction-related disease, fibrosis, respiratory disease, and the like.本發明提供一種以通式(I-1)表示的化合物(式中，所有記號係如說明書所記載。)，其由於藉由將2個環狀基(特別是苯氧基)導入特定之取代位置上而具有強力的人類S1P2拮抗活性，因此可成為S1P2介導性疾病，例如起因於血管收縮的疾病、纖維化、呼吸系統疾病等之治療劑。
