National University Corporation Kobe University;Toray Industries, Inc.;Tokyo Metropolitan Institute of Medical Science;University of Indonesia;Indonesian Institute Of Sciences (LIPI)
发明人:
申请号：
EP13841603.7
公开号：
EP2902485A1
申请日:
2013.09.27
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Provided are a HCV particle formation promoter capable of promoting formation of HCV particles in culture cells, and a method of enhancing production of HCV particles. Also provided are a method of evaluating an anti-HCV agent candidate substance, and a method of producing a HCV vaccine. The HCV particle formation promoter comprises as an active ingredient a statin or a pharmaceutically acceptable salt thereof. Addition of the statin or pharmaceutically acceptable salt thereof to HCV-infected culture cells can promote formation of infectious HCV particles and enhance production of the particles. In addition, an anti-HCV agent candidate substance is evaluated by culturing HCV-infected cells in the presence of the HCV particle formation promoter and the anti-HCV agent candidate substance. Further, a HCV vaccine is produced by using HCV particles produced by the method of enhancing production of HCV particles.
