NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY;TORAY INDUSTRIES, INC.;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE;UNIVERSITY OF INDONESIA;INDONESIAN INSTITUTE OF SCIENCES (LIPI)
发明人:
Hak Hotta,Chie Aoki,Takaji Wakita,Soedarmono Pratiwi,Sitompul Ratna,Hakim Lukman,Kardono Leonardus
申请号：
US14432076
公开号：
US20150258189A1
申请日:
2013.09.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A HCV particle formation promoter is capable of promoting formation of HCV particles in culture cells, and a method enhances production of HCV particles. A method evaluates an anti-HCV agent candidate substance, and a method produces a HCV vaccine. The HCV particle formation promoter includes as an active ingredient a statin or a pharmaceutically acceptable salt thereof. Addition of the statin or pharmaceutically acceptable salt thereof to HCV-infected culture cells can promote formation of infectious HCV particles and enhance production of the particles. In addition, an anti-HCV agent candidate substance is evaluated by culturing HCV-infected cells in the presence of the HCV particle formation promoter and the anti-HCV agent candidate substance. Further, a HCV vaccine is produced by using HCV particles produced by the method of enhancing production of HCV particles.
