ＴＲＰＭ８拮抗劑及其治療用途农业专利-农业学术服务平台

发明人:: BISWAS, KAUSTAV,毕斯瓦兹　考斯达夫,畢斯瓦茲　考斯達夫,BROWN, JAMES,布朗　詹姆士,CHEN, JIAN J.,陈　将Ｊ,陳　將Ｊ,GORE, VIJAY KESHAV,高尔　维杰　凯雪夫,高爾　維傑　凱雪夫,HARRIED, SCOTT,哈里德　史考特,HORNE, DANIEL B.,霍恩　丹尼尔Ｂ,霍恩　丹尼爾Ｂ,KALLER, MA,毕斯瓦兹考斯达夫,畢斯瓦茲考斯達夫,布朗詹姆士,陈将J,陳將J,高尔维杰凯雪夫,高爾維傑凱雪夫,哈里德史考特,霍恩丹尼尔B,霍恩丹尼爾B

摘要：: Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.式I化合物適用作TRPM8拮抗劑。該等化合物適用於治療多種TRPM8介導之病症及病狀且可用於製備適用於治療該等病症及病狀之藥劑及醫藥組合物。該等病症之實例包括(但不限於)偏頭痛及神經性疼痛。式I化合物具有以下結構：其中變數之定義係在本文中提供。