Medical systems, devices and methods are provided for accessing a bodily- opening that, among other things, are safe and reliable, and facilitate manipulation of a medical instrument. The medical access device (20) generally includes an elongated flexible sheath (22) and a port (30) connected to the distal end of the flexible sheath. The sheath defines a sheath lumen (24) and a longitudinal axis. The port has an interior surface (32) defining a passageway (34) and an exterior (36) surface that is tapered in a distal direction. The passageway is in communication with the sheath lumen. The exterior surface of the port defines a radially opening channel (40) sized to receive at least a portion of the tissue therein.
