Provided is a fully Human Antibody Binding to Antigen or a fragment of a Human Antibody that specifically binds and Inhibits or interferes with at least one activity of Human Angiopoietin Like Protein 3 (hangptl3).The Anti Human hangptl3 are useful in the treatment of diseases or Disorders associated with Angptl3, such as hyperlipidemia, hyperlipoproteinemia and including dyslipidemia, hypertriglyceridemia, Hypercholesterolemia, quilomicronemia and so on.In addition, the anti hangptl3 can be administered to a subject in need to prevent or treat diseases or disorders, for which the abnormal Lipid Metabolism is a risk factor.These Disorders or diseases including cardiovascular diseases, such as atherosclerosis and Coronary Artery Disease acute pancreatitis non alcoholic steatohepatitis (Nash) diabetes Obesity and the like.Claim 1: isolated a Human Antibody, or a fragment of Antigen Binding to the same, that specifically binds to human angiopoietin Like Protein 3 (hangptl3 SEC ID no. 161) that neutralizes and reduces interferes, or at least one of the hangptl3 activity.Se proporciona un anticuerpo completamente humano o un fragmento de unión a antígeno de un anticuerpo humano que se une específicamente e inhibe o interfiere con al menos una actividad de la proteína 3 de tipo angiopoyetina humana (hANGPTL3). Los anticuerpos anti-hANGPTL3 humanos son útiles en el tratamiento de enfermedades o trastornos asociados con ANGPTL3, tales como hiperlipidemia, hiperlipoproteinemia y dislipidemia, incluyendo hipertrigliceridemia, hipercolesterolemia, quilomicronemia y así sucesivamente. Además, los anticuerpos anti-hANGPTL3 pueden administrarse a un sujeto que los necesite para prevenir o tratar enfermedades o trastornos, para los que el metabolismo anómalo de lípidos es un factor de riesgo. Dichos trastornos o enfermedades incluyen enfermedades cardiovasculares, tales como aterosclerosis y enfermedades de la arteria coronaria pancreatitis aguda esteatohepatitis no alcohólica (EH
