A compound of formula I e.g. N-(2-(2-chlorophenyl)-S,6-dimethylpyrimidin-4-yl)-S-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine or a pharmaceutically acceptable salt thereof, wherein: RX is alkyl and RY is alkyl for treating or lessening the severity of a disease or condition selected from diabetes, osteoporosis, Alzheimers disease, Huntingtons disease, Parkinsons disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease), multiple sclerosis (MS), schizophrenia, leukocytopenia, stroke, and rheumatoid arthritis, stroke, spinal cord injury, traumatic brain injury, Charcot-Marie- Tooth, and diabetic neuropathy.
