The present invention relates to the 3- cycloalkyl amino pyrrolidin derivatives as chemokine receptors adjusting control agent, more particularly to the 3- cycloalkyl amino pyrrolidin derivatives of Formulas I: (wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as herein defined), they can be used as the adjusting control agent of chemokine receptor activity. Specifically, these compounds can be used as the adjusting control agent of chemokine receptors, the more specifically adjusting control agent of CCR2 and/or CCR5 receptor. The compound of the present invention and composition can be in conjunction with chemokine receptors, such as CCR2 and/or CCR5 chemokine receptors, it can be treated with what and chemotactic factor (CF), such as CCR2 and/or the related disease of CCR5 activity, such as atherosclerosis, restenosis, lupus, organ-graft refection and rheumatoid arthritis.本發明涉及作為趨化因子受體調控劑的3-環烷基氨基吡咯烷衍生物，具體涉及式I的3-環烷基氨基吡咯烷衍生物：(其中R1、R2、R3、R4、R5、R6、R7、X、Y和Z是如本文所定義的)，它們可用作趨化因子受體活性的調控劑。確切而言，這些化合物可用作趨化因子受體的調控劑，更具體為CCR2和／或CCR5受體的調控劑。本發明的化合物和組合物可以與趨化因子受體、例如CCR2和／或CCR5趨化因子受體結合，可用於治療與趨化因子、例如CCR2和／或CCR5活性有關的疾病，例如動脈粥樣硬化、再狹窄、狼瘡、器官移植排斥和類風濕性關節炎。
