Although as for this invention, the chemical compound of the chemical formula 1 which shows the CCR2 (chemokine receptor 2) competition effect, being something regarding this salt or isomer, as for this kind of chemical compound, the riumachi characteristic arthritis, the artery muscardine and the multiple sclerosis, it remedies the various diseases which it is related with asthma, and other CCR2, it prevents or improves it is useful.< Conversion 1 >In the above-mentioned chemical formula 1, R, R, R, R, R, R, R, R and R are, as defined with this bill.本発明は、CCR2(chemokine receptor 2)拮抗効果を示す化学式1の化合物、これの塩又は異性体に関するものであって、このような化合物は、リウマチ性関節炎、動脈硬化症、多発性硬化症、喘息、及びその他のCCR2と関連した種々の疾患を治療、予防又は改善するのに有用である。【化1】上記化学式1において、R1、R2、R3、R4、R5、R6、R7、R8及びR9は、本明細書で定義されたとおりである。
