1. The liposome composition obtained by mixing a water-soluble organic solution in which the phospholipid and cholesterol are in a total concentration of from 100 to 200% wt. / Vol. a water-soluble organic solvent with a first aqueous phase solution in an amount of from 3/1 to 12/1 in a volume ratio of water-soluble organic solution to yield an emulsion, wherein the total concentration of phospholipid and cholesterol in the resulting mixed phase is from 15 to 50% by weight ./ob., followed by replacement of the external solution of the emulsion solution, constituting a second aqueous phase, wherein the ion gradient is formed between the inner region of the liposome membrane the aqueous phase, wherein the aqueous phase is soda inner region INH first aqueous phase solution and the aqueous outer region of the liposome membrane phase, wherein the aqueous phase of the outer region comprises a second aqueous solution fazy.2. The liposome composition according to Claim. 1, in which the ion gradient is a proton gradient pH, and the liposome composition is characterized by such pH gradient, the value of pH of the aqueous phase inside the liposomes region lower than the pH of the aqueous phase liposomy.3 outer region. The liposome composition according to Claim. 1 or 2, wherein the liposome comprises an aqueous phase in the inner region of the multilayer membrane is characterized by an average particle diameter in terms of external diameter is 2.5 .mu.m or more, and characterized by at least 12-layer strukturoy.4. Liposomal preparation containing lekarstvennoesredstvo introduced into the aqueous phase in the inner region of the liposome composition according to any one of claims. 1-3 by applying the ion grad1. Липосомальная композиция, полученная путем смешивания водорастворимого органического раствора, в котором фосфолипид и холестерин содержатся в общей концентрации от 100 до 200% масс./об. в водорастворимым органическом растворителе, с раствором первой водной фазы в количес
