The present invention relates to the neutralizing antibodies and its antibody fragment with the high-titer for neutralizing hCMV, wherein the antibody and antibody fragment are specific to two or more hCMV gene UL products of what one or combination. The invention further relates to the immortalised B-cells for generating these antibody and antibody fragment, and are related to the epitope in conjunction with these antibody and antibody fragment. Moreover, it relates to the application of antibody, antibody fragment and epitope in screening technique and medical diagnosis on disease, prevention or treatment.本發明涉及具有中和hCMV的高效價的中和抗體和其抗體片段，其中所述抗體和抗體片段對於一個、或組合的兩個或更多hCMV基因UL産物是特異性的。本發明還涉及産生這些抗體和抗體片段的永生化B細胞，並且涉及結合這些抗體和抗體片段的抗原表位。另外，本發明涉及抗體、抗體片段和抗原表位在篩選方法以及疾病診斷、預防或治療中的應用。
