HORSLEY, HELEN TRACEY,MEARS, RICHARD JOHN,NEUSS, JUDI CHARLOTTE,REUBERSON, JAMES THOMAS
申请号：
CA3007975
公开号：
CA3007975A1
申请日:
2016.12.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A series of 1,2,6,7,9,9a-hexahydropyrazino[1,2-d][1,2,4]triazin-4-one derivatives, substituted in the 8-position by an optionally substituted fused bicyclic heteroaromatic group, and in the 3-position by a range of functional groups,being selective inhibitors of phosphatidylinositol-4-kinase IIIß (PI4KIIIß) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders； viral diseases and malaria； and organ and cell transplant rejection.
