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FORMULATIONS EFFERVESCENTES STABLES A BASE DE BISPHOSPHONATE PRESENTANT DES CARACTERISTIQUES DE SOLUBILISATION RAPIDE
专利权人:
EFFRX PHARMACEUTICALS SA
发明人:
HAYWARD, MARSHALL A.,SCHMIDT, TIMO
申请号:
CA2820019
公开号:
CA2820019A1
申请日:
2011.12.05
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising. an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5 - 20 °C; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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