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anesthesia induction methods
专利权人:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
ROBERT J. BROSNAN
申请号:
BR112015000475
公开号:
BR112015000475A2
申请日:
2013.03.14
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
abstract of the disclosure [0234] the present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor for determining the molar water solubility of the anesthetic. the invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. the invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods. Patent abstract: "Methods of inducing anesthesia". The present invention provides methods for determining the selectivity of an anesthetic by an anesthetic sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic by an anesthetic sensitive receptor by altering or modifying the anesthetic to have greater or lesser solubility in water. The invention further provides methods for inducing anesthesia in an individual by administering via the airways (e.g., by inhalation or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.abstract of the disclosure [0234] the present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. the invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. the invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anest
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