CAGE, PETER,FURBER, MARK,KHAN, ZARA,NEEDHAM, MAURICE,NEWHAM, PETER
申请号：
EP07747987
公开号：
EP2010175A4
申请日:
2007.04.04
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Use of a compound of formula (I): wherein: R<；SUP>；1 <；/SUP>；is phenyl optionally substituted by halogen, cyano, C<；SUB>；1-4 <；/SUB>；alkyl or C<；SUB>；1-4 <；/SUB>；haloalkyl； R<；SUP>；2 <；/SUP>；is hydrogen, C<；SUB>；1-6 <；/SUB>；alkyl or C<；SUB>；3-6 <；/SUB>；cycloalkyl； and R<；SUP>；3 <；/SUP>；is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0； or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states).
