The present invention relates to material engineering and could be applied in odontology or other kind of surgery for bone tissue regeneration in a defect site. The aim of this invention is to prepare a porous three dimensional cellulose-based biocompatible scaffold of good osteoconductive and mechanical properties with the structure like that of a natural bone. To achieve the above object, the present invention provides a composite comprising cellulose and biogenic bone particles at a ratio (w/w) 1 :0.12-6.0, wherein the diameter of the particles is 0.01-2000 microns. In a separate case a bone material which comprises inorganic compounds and polysaccharide chitin could be used as a biogenic bone. In a separate case the surface of the scaffold could be coated with collagen, platelet- rich fibrin, various growth factors, therapeutic additives, stem cells. The three dimensional porous scaffold of the natural bone morphology is prepared by inserting biogenic bone particles into a cellulose gel during its formation from cellulose acetate at a ratio 1 :0.12- 6.0, afterwards loading the gel with an aqueous 10-30 % ethanol solution and freeze-dried or extracted with carbon dioxide at supercritical conditions at 24-70 MPa and 35-80°C temperature. The resulting scaffold could be ground to granules of a desired size and/or the pasta could be prepared.La présente invention concerne lingénierie de matériau et pourrait être appliquée en odontologie ou un autre type de chirurgie pour la régénération de tissu osseux dans un site de défaut. Lobjectif de cette invention est de préparer un échafaudage biocompatible à base de cellulose tridimensionnel ayant de bonnes propriétés ostéoconductrices et mécaniques ayant une structure similaire à celle dun os naturel. Pour réaliser lobjet ci-dessus, la présente invention concerne un composite comprenant de la cellulose et des particules dos biogéniques à un rapport (m/m) 1:0,12 à 6,0, dans lequel le diamètre des particules est de 0,01 à 200
