CHUNTHARAPAI ANAN,KIM JIN K.,PRESTA LEONARD G.,STEWART TIMOTHY
申请号:
SI200230973
公开号:
SI1362105T1
申请日:
2002.01.29
申请国别(地区):
SI
年份:
2012
代理人:
摘要:
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-± monoclonal antibodies with broad reactivity against various IFN-± subtypes. The invention further relates to the use of such anti-IFN-± antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-±, in particular, autoimmune disorders such as insulin-dependant diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).