A composition includes a silk protein layer and a hydrophilic glycoside compound, and the hydrophilic glycoside compound is coated on the silk protein layer. Furthermore, the invention also provides the use of the composition for manufacturing a wound dressing and the manufacturing method of the composition.一種組合物,包括:蠶絲蛋白主體層、以及親水性苷類化合物,親水性苷類化合物為附著於蠶絲蛋白主體層。此外,本發明尚提供此組合物用於製備傷口敷料的用途與製造方法。