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Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
专利权人:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
发明人:
Sanghapal Damodhar Sawant,Lakshma Reddy Ginnereddy,Srinivas Mahesuni,Sajad Hussain Syed,Mohd Ishaq Dar,Amit Nargotra,Priya Mahajan,Ram Asrey Vishwakarma
申请号:
US15115573
公开号:
US10017511B2
申请日:
2014.10.20
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in vivo efficacy and PK profile and a process for the preparation thereof. The present invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in vivo efficacy. These compounds can be used in the treatment of male erectile dysfunction or in the treatment of impotence.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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