#$%^&*AU2019100971A420191003.pdf#####ABSTRACT The invention relates to a milk powder and a preparation method and use thereof, in particular to a milk powder containing lactoferrin and sialic acid, a preparation method thereof and use thereof. It belongs to the field of food, especially dairy technology. A lactoferrin and sialic acid-prepared milk powder according to the present invention, which is composed of the following materials in parts by weight, and the ratio of the components and parts by weight is: 400-600 parts of instant whole milk powder, and 400-450 parts of instant skim milk powder, 500-700 parts of whey protein powder, 0.5-2 parts of taurine, 300-350 parts of anhydrous glucose, 120-130 parts of oligofructose, furthermore including: 1-3 parts of lactoferrin 20-40 parts of sialic acid. The product of the invention provides nutrition mainly by the combination of lactoferrin and sialic acid, supplemented by other nutrients, so that the nutrition of the milk powder is more perfect, and the method of mixing powder is studied, so that the final product is more uniform and beneficial to human body absorption and Utilize, while avoiding the problem of affecting the quality of the final product due to uneven mixing.