Hong Liang;Javier Fernando Chaparro Riggers;Yasmina Noubia Abdiche;Jaume Pons;Julie Jia Li Hawkins;Bruce Charles Gomes;Yuli Wang
发明人:
Hong Liang,Yasmina Noubia Abdiche,Javier Fernando Chaparro Riggers,Bruce Charles Gomes,Julie Jia Li Hawkins,Jaume Pons,Yuli Wang
申请号：
US13225265
公开号：
US08426363B2
申请日:
2011.09.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
