BRUCE CHARLES GOMES,JULIE JIA LI HAWKINS,XIAYANG QIU,YULI WANG
申请号：
IN1816/DELNP/2011
公开号：
IN271336B
申请日:
2011.03.11
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention! further provides a method of obtaining such antibodies and antibody-encoding nuceic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
