variants of the major timothy grass phl p 1 allergen, their folding forms lm and hm, their uses and their preparation and purification processes, DNA molecule, recombinant DNA expression vector and its use, and pharmaceutical compositions
MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
发明人:
HELMUT FIEBIG,OLIVER CROMWELL,ROLAND SUCK
申请号：
BR0313613
公开号：
BRPI0313613B1
申请日:
2003.07.31
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"variants of the main phl p1 allergen of timothy grass". The present invention relates to variants of the main phl1 Timothy grass allergen characterized by the fact that a hitherto un possible preparation of monomeric molecules which are soluble and stable in the physiological environment can be carried out with the help of of prokaryotic expression systems and subsequent purification thereof."variantes do principal alérgeno phl p1 de capim-timóteo". a presente invenção refere-se a variantes do principal alérgeno phl p 1 de capim-timóteo, caracterizadas pelo fato de que uma preparação, até então não possível, de moléculas monoméricas que são solúveis e estáveis no meio fisiológico, pode ser realizada com a ajuda de sistemas de expressão procariótica e subseqüente purificação das mesmas.
