Tuberculosis is a respiratory transmitted disease, in which some species of mycobacteria are pathogenic for several animal species and are responsible for two important human chronic diseases, such as Tuberculosis and Leprosy. Development of new chemical entity, as a drug, is a risky, time and money consuming preposition, so here the main objectives is to design and synthesize the molecules having therapeutic importance. From literature survey it was found that Pyridinofusedtriazole is an important heterocyclic pharmacophore in drug discovery, and the compounds carrying different substituents in the triazolopyridine structure are associated with a wide range of biological activities such as anti-inflammatory, anticonvulsant, analgesic, antifungal, antibacterial and anti- tubercular activities. Further thiazolidin-4-one moiety has also shown to exhibit potent anti-tubercular, antifungal and antibacterial activities. Therefore pyridinofusedtriazole associated with thiazolidin-4-one derivatives were synthesized and confirmed by physiochemical and spectral data. Subsequent Biological screening was done for their anti-tubercular, antibacterial, antifungal activity using Rifampicin, Ciprofloxacin and Fluconazole for anti-tubercular, antibacterial and antifungal screening. Compounds with electron withdrawing group were found most active in the tuberculosis as well as antibacterial, antifungal activity which suggest that substituted phenyl ring shows more activity against mycobacteria, bacteria and fungi.
