Transdermal micrneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate, a micrneedle unit, a signal processing unit and a power supply unit. The micrneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheet provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately .本發明係為一種連續經皮微針監測系統,此監測系統包含:基板、微針單元、訊號處理單元及電源單元。微針單元至少包含排列於基板上作為工作電極的第一微針組和作為參考電極的第二微針組,每一微針組至少包含一微針,第一微針組係包含至少一薄片,每一薄片上至少設置一穿孔,穿孔邊緣設置有一突刺,其中一薄片上的穿孔係供其餘的薄片上相對位置的穿孔邊緣的突刺穿過,且該些突刺互相分離。10‧‧‧基板20‧‧‧微針單元22‧‧‧第一微針組24‧‧‧第二微針組26‧‧‧第三微針組30‧‧‧可撓性墊片32‧‧‧開口40‧‧‧電路板42‧‧‧電接點44‧‧‧電接點46‧‧‧電接點50‧‧‧外蓋
