Transdermal microneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate (10), a microneedle unit (20), a signal processing unit (41) and a power supply unit (43). The microneedle unit (20) at least comprises a first microneedle set (22) used as a working electrode and a second microneedle set (24) used as a reference electrode, the first and second microneedle sets (22, 24) arranging on the substrate (10). Each microneedle set comprises at least a microneedle. The first microneedle set (22) comprises at least a sheet (222) having a through hole (2222) on which a barbule (2224) forms at the edge. One of the sheets provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.
