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COMPOSITION, INCLUDING COMPLEX (s) RNA AND FREE mRNA FOR IMPLEMENTATION OR IMPROVEMENT OF THE MAMMAL ANSWERS RESPONSE, AND ITS APPLICATIONS
专利权人:
КУРЕВАК ГМБХ (DE)
发明人:
ФОТИН-МЛЕЧЕК Мариола (DE),ФОСС Зёнке (DE)
申请号:
RU2011116931/15
公开号:
RU2011116931A
申请日:
2009.09.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Immunostimulating composition, including! a) an adjuvant component, comprising or consisting of at least one (s) RNA, combined with a cationic or polycationic compound, and! b) at least one free mRNA encoding at least one therapeutically active protein, antigen and / or antibody! moreover, the immunostimulating composition is capable of inducing or enhancing the innate and optionally adaptive immune response in a mammal. ! 2. The immunostimulating composition according to claim 1, wherein at least one adjuvant component RNA (s) is selected from a short RNA oligonucleotide encoding RNA, including mRNA, immunostimulating RNA, siRNA, antisense RNA or RNA switches, ribozymes or aptamers. ! 3. The immunostimulating composition according to claim 1 or 2, in which at least one (s) RNA adjuvant component is mRNA. ! 4. The immunostimulating composition according to one of claims 1 or 2, in which at least one free mRNA and at least one (s) RNA of the adjuvant component are identical to each other. ! 5. The immunostimulating composition according to one of claims 1 or 2, in which at least one free mRNA and at least one (s) RNA of the adjuvant component are different. ! 6. The immunostimulating composition according to one of claim 1 or 2, in which the N / P ratio of and (RNA) to the cationic or polycationic compound in the adjuvant component is in the range of about 0.1-10, including the range of about 0.3-4, about 0.5-2, about 0.7-2 and about 0.7-1.5. ! 7. An immunostimulating composition according to one of claims 1 or 2, in which the molar ratio (s) of the RNA of the adjuvant component to at least one free mRNA in1. Иммуностимулирующая композиция, включающая ! а) адъювантный компонент, включающий или состоящий по меньшей мере из одной (и)РНК, объединенный с катионным или поликатионным соединением, и ! б) по меньшей мере одну свободную иРНК, кодирующую по меньшей мере один терапевтически активный белок, антиген и/или антитело, ! причем иммуностимулирующая композиция сп
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