Desai, Manoj C.,Hong, Allen Y.,Hui, Hon C.,Liu, Hongtao,Vivian, Radall W.,Xu, Lianhong,DESAI MANOJ C,DESAI, MANOJ C.,HONG ALLEN Y,HONG, ALLEN Y.,HUI HON C,HUI, HON C.,LIU HONGTAO,LIU, HONGTAO,VIVIAN RADALL W,VIVIAN, RADALL W.,XU LIANHONG,XU, LIANHONG
申请号：
ES12167596
公开号：
ES2602784T3
申请日:
2008.02.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A pharmaceutical composition comprising a compound of the formula IIB: ** Formula ** or a salt, solvent, stereosiomer and / or ester, wherein: R10a and R10b are each independently H or -C1-4 alkyl； R12 is H or -CH3； R13 is - (CH2) 0-3CR17R18NR20R21, - (CH2) 0-3CR17R18NR17C (O) NR20R21, - (CH2) 1-3C (O) R22, - (CH2) 1-3S (O) 2R22 or - (CH2) 1-3-R23； R14 and R15 are each independently H, -C1-4 alkyl or arylalkyl； R17 and R18 are each independently H or -C1-3 alkyl； R19 is H, -C1-4 alkyl or arylalkyl； R20 and R21 are each independently H, -C1-3 alkyl, -C (O) R17 or -S (O) 2R17； or R20 and R21, together with the nitrogen atom to which they are attached, form an unsubstituted or substituted 5-6 membered heterocyclyl ring containing 1-2 heteroatoms selected from the group consisting of N and O； R22 is H, -C1-3alkyl, -OR19 or -NR20R21； and R23 is an unsubstituted or substituted 5-6 membered heterocyclyl ring containing 1-2 heteroatoms selected from the group consisting of N and O； wherein the 5-6 membered heterocyclyl ring said unsubstituted or 5-6 membered substituted by R20 and R21 and the 5-6 membered unsubstituted or substituted 5-6 membered heterocyclyl ring R23 are each independently unsubstituted or substituted with a C1-2 alkyl, a pharmaceutically acceptable carrier or excipient and at least one additional therapeutic agent selected from the group consisting of a nucleotide reverse transcriptase inhibitor for HIV.Una composición farmacéutica que comprende un compuesto de la fórmula IIB: **Fórmula** o una sal, solvente, estereosiómero y/o éster , donde: R10a y R10b son cada uno independientemente H o -C1-4 alquil； R12 es H or -CH3； R13 es -(CH2)0-3CR17R18NR20R21, -(CH2)0-3CR17R18NR17C(O)NR20R21, -(CH2)1-3C(O)R22, - (CH2)1-3S(O)2R22 o -(CH2)1-3-R23； R14 y R15 son cada uno independientemente H, -C1-4 alquil o arilalquil； R17 y R18 son cada uno independientemente H o -C1-3 alquil； R19 es H, -C1-4 alquil o arilalquil； R20 y R21 son cada uno independientemente H, -C1-3 a
