SUNG, HSING WEN,宋信文,LIN, WEI CHIH,林威志,LIN, SHU JYUAN,林淑娟
申请号：
TW106109585
公开号：
TW201834637A
申请日:
2017.03.22
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present disclosure provides a sustained-release composition including sodium hydrosulfide and a carrier. The carrier is provided for carrying the sodium hydrosulfide with an effective amount and includes a first component and a second component. The first component includes a paraffin wax, and the second component includes a fatty alcohol, a fatty acid or a phospholipid. Thereby, the present disclosure can form a barrier to protect the sodium hydrosulfide from a rapid dissociation after encountering water. Hydrogen sulfide is then released slowly and continuously for providing a long-term therapeutic effect, and the frequency of providing the sodium hydrosulfide can be reduced.本發明提供一種緩釋型組成物，其包含硫氫化鈉與載體。載體係用以承載有效量之硫氫化鈉且可包含第一成份與第二成份，其中第一成份包含石蠟，而第二成份包含脂肪醇、脂肪酸或磷脂質。藉此，本發明可於硫氫化鈉外圍形成一層屏障以防止硫氫化鈉遇水後快速分解，進而緩慢且持續地釋放硫化氫而能提供長效治療的效果，並大幅減少硫氫化鈉的注入頻率。
