An object of the present invention is to provide a new medicinal drug, a method, use, and a compound; which are for refractory leukemia associated with MLL, for which existing chemotherapy is not effective. According to the present invention, there is provided a medicinal drug for preventing or curing leukemia associated with MLL, containing 5-hydroxy-1H-imidazole-4-carboxamide, or a salt thereof or a hydrate thereof.