Disclosed is the use of Compound A for the manufacture of a medicament for treating a patient suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance, wherein Compound A is (S)-5-aminomethyl-1-(5,7- difluoro-1,2,3,4-tetrahydronaphth-2-yl)-2,3-dihydro-2-thioxo-1H-imidazole, (R)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphth-2-yl)-2,3-dihydro-2-thioxo-1H-imidazole, a mixture thereof, or a pharmaceutically acceptable salt thereof.