5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain
David Miller;Kevin Merchant;Katherine Hazel;William Farnaby;Charlotte Fieldhouse;David Livermore;Catrina Kerr;Natasha Kinsella
发明人:
William Farnaby,Charlotte Fieldhouse,Catrina Kerr,Natasha Kinsella,David Livermore,Kevin Merchant,David Miller,Katherine Hazel
申请号：
US14131343
公开号：
US09180122B2
申请日:
2012.07.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or fluorine, one of A and B is R2, the other is a group —X—Y—R3. R3 represents a carbocyclic or heterocyclic ring. Further variables are as defined in the specification. Also claimed are—processes for their preparation, pharmaceutical compositions containing them and their use in therapy of diseases such as schizophrenia, cognitive disorders and pain by modulating the D-amino acid oxidase enzyme (DAAO).
