Chimeric immunoglobulin monomer dimer hybrids

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专利权人:

BIOGEN IDEC HEMOPHILIA INC.

发明人:

PETERS, ROBERT, T.,MEZO, ADAM, R.,RIVERA, DANIEL, S.,BITONTI, ALAN, J.,STATTEL, JAMES, M.,LOW, SUSAN, C.

申请号：

DK04775946

公开号：

DK1625209T3

申请日:

2004.05.06

申请国别(地区):

DK

年份:

2013

代理人:

摘要：

A chimeric protein is synthesized by a) recombinantly expressing a fusion protein comprising at least a portion of an immunoglobulin constant region and a splicing protein capable of forming a C terminus thioester on the portion of an immunoglobulin constant region； b) adding a thiol cofactor to the fusion protein of a)； and c) adding at least one biologically active molecule having an N terminal cysteine.

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