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LIQUID STABLE VIRAL VACCINES
专利权人:
ИНТЕРВЕТ ИНТЕРНЭШНЛ Б.В. (NL)
发明人:
О'КОННЕЛЛ Кевин (US),ЦЯО Чжисун (US),ОКОННЕЛЛ Кевин (US)
申请号:
RU2015109724
公开号:
RU2015109724A
申请日:
2013.08.16
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A stable liquid vaccine that contains live attenuated virus of dogs or cats, 10-30% (w / v) sugar excipient and amino acid; where a stable liquid vaccine has a pH value of from 6.0 to 8.0; and where the amino acid is selected from the group consisting of arginine and methionine; moreover, if the amino acid is arginine, its final concentration in a stable liquid vaccine is from 0.15 to 0.6 M; and moreover, if the amino acid is methionine, its final concentration in a stable liquid vaccine is from 0.025 to 0.3 M.2. A stable liquid vaccine according to claim 1, wherein the live attenuated dog virus is selected from the group consisting of dog plague virus, type 2 adenovirus, dog parvovirus and dog parainfluenza virus or any combination thereof. The stable liquid vaccine according to claim 2, wherein the dog parvovirus (CPV) is selected from the group consisting of CPV-2, CPV-2a, CPV-2b, CPV-2c and recombinant CPV containing the heterogeneous CPV-2c / CPV-2.4 genome. The liquid stable vaccine according to claim 3, wherein CPV-2c has an ATCC PTA-13492.5 account number. The stable liquid vaccine of claim 2, wherein the dog parainfluenza virus is a recombinant vector that encodes and expresses a heterogeneous antigen. A stable liquid vaccine according to claim 1, which further comprises a component selected from the group consisting of 0.4-1.6% (w / v) gelatin, 0.5-2.0% (w / v. ) a proteolytic hydrolyzate of whole casein, 0.25-1.0% (v / v) ethanol, chelator, buffer, antibiotic, adjuvant, or any combination thereof. 7. A stable liquid vaccine according to claim 6, wherein the buffer is selected from the group consisting of 2.5-50 mM Tris and 2.5-50 mM Tris with 2.5-50 mM histidine. The stable liquid vaccine of claim 1, wherein the sugar excipient is selected from the group consisting of sucrose, sorbitol, and a combination of sugar and1. Жидкая стабильная вакцина, которая содержит живой аттенуированный вирус собак или кошек, 10-30% (мас./об.) сахарного вспомогательного в
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