Benzimidazole derivatives as pi3 kinase inhibitors

• 收藏
• 分享

专利权人:

GLAXOSMITHKLINE LLC

发明人:

Qu Junya,Rivero Ralph,Sanchez Robert,Tedesco Rosanna

申请号：

NZ60806911

公开号：

NZ608069A

申请日:

2011.09.23

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Provided are benzimidazole derivatives of the general formula (I), where the variables are as described in the specification. A preferred compound is 2-methyl-1-{ [2-methyl-3-(trifluoromethyl)phenyllmethyl} -6-( 4-morpholinyl)-1H-benzimidazole-4-carboxylic acid. The compounds can inhibit members of the phosphoinositide 3’ OH kinase (PI3K) family such as, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Further provided is the use of the compounds in the treatment of various disease states. A preferred use of the compounds is in the treatment of cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/