The Brigham and Women's Hospital, Inc.;President and Fellows of Harvard College;Massachusetts Institute of Technology;The Children's Medical Center Corporation
发明人:
申请号：
EP08839738.5
公开号：
EP2217269B1
申请日:
2008.10.12
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.
