NAIMISHA TRIVEDI,CHARLES BAKER-GLENN,HERV VAN DE POL,ELISABETTA ARMANI,GABRIELE AMARI
申请号：
ARP160101574
公开号：
AR104822A1
申请日:
2016.05.30
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Phosphodiesterase 4 (PDE4) enzyme inhibitors as antagonists of M3 muscarinic receptors, methods for preparing them, compositions containing them and their use in therapy. Claim 1: A compound characterized in that it responds to the general formula (1) wherein in each case, R¹ is hydrogen or is independently selected from the group consisting of a halogen, a C₁₋₄ alkyl,a C₁₋₄ alkoxy,1. Halide c833383241；A hydroxy group or a group - so8322； - n8310； - r8311；-Cn, - No. 831222； - No. 183228313；-8310； 8311；-CONR R o -NR CORwhere the C₁₋₄ alkyl may be substituted with one or more groups that are selected from a C₃₋₇ cycloalkyl,One hydroxyl group or one group - 8310r8311；There, one or more halogens or c833183278c833278c823238c8c8c8c8c8c8c8c8c8c8c8c8c8c8c8c8c8c8c8l8c8c8c8c8c8c8c8c8c8c8c8l8c8c8c8c8c8c8c8c8c can be usedwhere R⁶ is hydrogen or a C₁₋₆ alkyl；R⁷ is hydrogen or a C₁₋₆ alkyl；R⁸ is hydrogen or a C₁₋₆ alkyl；R⁹ is hydrogen or a C₁₋₆ alkyl；n is an integer that is in the range of 1 to 3； in each case, R² is hydrogen or is selected from the group consisting of a halogen, a C₁₋₄ alkyl,a C₁₋₄ alkoxy,1. Halide c833383241；One hydroxyl group or one group - so83222； nr.83040； R1,-CN or -NR¹²SO₂R¹³,wherein the C₁₋₄ alkyl or C₁₋₄ alkoxy may be substituted with one or more C₃₋₇ cycloalkyl groups,where R¹⁰ is hydrogen or a C₁₋₆ alkyl；R1 is hydrogen or c8332131 or 832626；R2 is hydrogen or c8332131 or 832626 asphalt；R¹³ is hydrogen or a C₁₋₆ alkyl；m is an integer that is in the range of 1 to 3； R³ and R⁴ are different or identical and are independently selected from the group consisting of hydrogen, a C₃₋₇ cycloalkylcarbonyl or a C₁₋₆ alkyl optionally substituted with one or more substituents that are selected from a C₁₋₄ alkoxy,One c8323-83318327a,a C₅₋₇ cycloalkenyl,1. Halide c83217c831832626；One c8323-83318327a,a C₅₋₇ cycloalkenyl,a C₂₋₆ alkenyl or a C₂₋₆ alkynyl；R83099 was elected at each meeting he attended independently of the group composed of CN. N；CF₃ or halogen atoms； k is
