ITOCHU CHEMICAL FRONTIER CORPORATION;OISHI KOSEIDO CO., LTD.
发明人:
MORI, TATSUYA,森达也,森達也,SAIDA, NAOYUKI,财田直之,財田直之
申请号：
TW101134883
公开号：
TW201318652A
申请日:
2012.09.24
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
In a non-aqueous patch containing lidocaine, the adhesive force of the preparation tends to lower with an increase in the content of lidocaine. To release an effective amount of lidocaine from a patch to the skin, it is a common practice to dissolve lidocaine using a solubilizing agent. However, an increase in the content of the solubilizing agent causes even more remarkable lowering of the adhesive force, which makes long-term adhesion impossible. A non-aqueous patch, wherein a biaxially stretching extensible fabric having a strength under 50% extension in the long side direction of not more than 2000 g/50 mm is used as a support for a lidocaine-containing ointment, and an ointment base contains a solubilizing agent together with lidocaine and/or a reaction product thereof.當調配於非水性貼附劑中之時，會有利多卡因(lidocaine)調配量越多，則製劑黏著力越弱的傾向，且為使調配於貼附劑中並能對皮膚釋放有效量，一般係利用溶解劑予以溶解，但若溶解劑增加，則黏著力降低會更加明顯，難以長時間貼附。本發明的非水性貼附劑中，作為含有利多卡因的膏體之支撐體，係設為長邊方向50%伸張時的強度在2000g/50mm以下，並具有雙軸延伸性伸長性的布製品，在膏體的基材中一併含有利多卡因及/或其反應物、以及溶解劑。
