ITOCHU CHEMICAL FRONTIER CORPORATION;OISHI KOSEIDO CO., LTD.
发明人:
MORI, TATSUYA,SAIDA, NAOYUKI
申请号：
CA2850024
公开号：
CA2850024A1
申请日:
2011.09.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
[Problem] In a non-aqueous patch containing lidocaine, the adhesive force of the preparation tends to lower with an increase in the content of lidocaine. To release an effective amount of lidocaine from a patch to the skin, it is a common practice to dissolve lidocaine using a solubilizing agent. However, an increase in the content of the solubilizing agent causes even more remarkable lowering of the adhesive force, which makes long-term adhesion impossible. [Solution] A non-aqueous patch, wherein a biaxially stretching extensible fabric having a strength under 50% extension in the long side direction of not more than 2000 g/50 mm is used as a support for a lidocaine-containing ointment, and an ointment base contains a solubilizing agent together with lidocaine and/or a reaction product thereof.
